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2025年

論文業績

原著

Gut mucin fucosylation dictates the entry of botulinum toxin complexes
Amatsu, S.*, Matsumura, T.*, Morimoto, C., Keisham, S., Goto, Y., Kohda, T., Hirabayashi, J., Kitadokoro, K., Katayama, T., Kiyono, H., Tateno, H., Zuka, M. & Fujinaga, Y.†.
Nat. Commun. 16, 10442.  doi: 10.1038/s41467-025-65384-w.
PMID:41290571

*: These two authors contributed equally to this work

​†: Correspondence author

2024年

論文業績

原著

Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin
Matsumura T*, Kitamura M*, Amatsu S, Yamaguchi A, Kobayashi N, Yutani M, Fujinaga Y†.
Microbiol Immunol. 2024 Sep 6.  doi: 10.1111/1348-0421.13171.
PMID:39239735

Botulinum neurotoxin X lacks potency in mice and in human neurons.
Gregg, B. M.*, Matsumura, T.*, Wentz, T. G., Tepp, W. H., Bradshaw, M., Stenmark, P., Johnson, E. A., Fujinaga, Y†. & Pellett, S†.
mBio. 15, e03106-23 (2024). doi: 10.1128/mbio.03106-23
PMID:38347673

*: These two authors contributed equally to this work

​†: Correspondence author

2023年

論文業績

原著

Growth prolongation of human induced pluripotent stem cell aggregate in three-dimensional suspension culture system by addition of botulinum hemagglutinin.
Yamamoto R, Sakakibara R, Kim MH, Fujinaga Y, Kino-Oka M.
J Biosci Bioeng. 2024 Feb;137(2):141-148. doi: 10.1016/j.jbiosc.2023.11.010.
PMID:​38110319

Adult-onset botulism in a Japanese woman with prolonged spore excretion. 
Kihara, K., Kajiyama, Y., Kimura, Y., Okazaki, S., Esa, N., Nobe, R., Shimizu, K., Ohno, K., Motooka, D., Matsumura, T., Shimazu, T., Nakamura, S., Fujinaga, Y. & Mochizuki, H.
J. Infect. Chemother. 29, 1172–1176 (2023). doi: 10.1016/j.jiac.2023.08.009
PMID:37598776

Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin.
Amatsu, S., Matsumura, T., Zuka, M. & Fujinaga, Y.
 J. Biol. Chem. 102944 (2023). doi: 10.1016/j.jbc.2023.102944
PMID:36707052

2022年

論文業績

原著

Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro
Nobuhide Kobayashi, Kimihiro Abe, Sachiyo Akagi, Mayu Kitamura, Yoshitake Shiraishi, Aki Yamaguchi, Masahiro Yutani, Sho Amatsu, Takuhiro Matsumura, Nobuhiko Nomura, Noriyuki Ozaki, Nozomu Obana, Yukako Fujinaga
Frontiers in Microbiology. 13 (2022). doi: 10.3389/fmicb.2022.720308
PMID:35185840

Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene
Takemori-Sakai, Y., Satou, K., Senda, Y., Nakamura, Y., Otani, H., Maekawa, A., Oe, H., Oshima, M., Yoneda-Nakagawa, S., Miyagawa, T., Sato, K., Ogura, H., Mori, M., Wada, T., Sakai, Y., Yutani, M., Matsumura, T., Fujinaga, Y., Gabata, T., Wada, T. & Iwata, Y. 
J Infect Chemother. 2022 Jan 22;S1341-321X(22)00026-5. doi: 10.1016/j.jiac.2022.01.015.
PMID:35078721

2021年

論文業績

原著

Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis
Iida, N., Mizukoshi, E., Yamashita, T., Yutani, M., Seishima, J., Wang, Z., Arai, K., Okada, H., Yamashita, T., Sakai, Y., Masuo, Y., Agustina, R., Kato, Y., Fujinaga, Y., Oshima, M., Honda, M., Lebreton, F., Gilmore, M. S. & Kaneko, S.
Nature Cancer. 1–16 (2021). doi:10.1038/s43018-021-00251-3
PMID:35121877

Effects of antibiotics on the viability of and toxin production by Clostridium botulinum
Yutani M, Matsumura T, Fujinaga Y.
Microbiol Immunol. 2021 Jul 5. doi: 10.1111/1348-0421.12928.
PMID:34219270

© Copyright

2020年

論文業績

原著

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B.
Matsumura T, Amatsu S, Misaki R, Yutani M, Du A, Kohda T, Fujiyama K, Ikuta K, Fujinaga Y.
Toxins (Basel). 2020 May 7;12(5):302. doi: 10.3390/toxins12050302.
PMID:32392791

Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.
Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T.
Int J Infect Dis. 2020 Feb;91:22-31. doi: 10.1016/j.ijid.2019.11.003.
PMID:31740408

総説

Functional Analysis of Botulinum Hemagglutinin (HA).
Matsumura T, Fujinaga Y.
Methods Mol Biol. 2020;2132:191-200. doi: 10.1007/978-1-0716-0430-4_20.
PMID:32306328

Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine.
Amatsu S, Fujinaga Y.
Methods Mol Biol. 2020;2132:183-190. doi: 10.1007/978-1-0716-0430-4_19.
PMID:32306327

2019年

論文業績

原著

Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host.
Seishima J, Iida N, Kitamura K, Yutani M, Wang Z, Seki A, Yamashita T, Sakai Y, Honda M, Yamashita T, Kagaya T, Shirota Y, Fujinaga Y, Mizukoshi E, Kaneko S.
Genome Biol. 2019 Nov 25;20(1):252. doi: 10.1186/s13059-019-1879-9.
PMID:31767028

Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior.
Shuzui E, Kim MH, Azuma K, Fujinaga Y, Kino-Oka M.
J Biosci Bioeng. 2019 Jun;127(6):744-751. doi: 10.1016/j.jbiosc.2018.11.014.
PMID:30660482

総説

[Mechanism of intestinal absorption of botulinum neurotoxin complex].
Matsumura T.
Nihon Saikingaku Zasshi. 2019;74(3):167-175. doi: 10.3412/jsb.74.167.
PMID:31787706

2018年

論文業績

原著

A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin.
Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M.
Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201700384.
PMID:29027750

Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption.
Amatsu S, Matsumura T, Yutani M, Fujinaga Y.
Microbiol Immunol. 2018 Feb;62(2):80-89. doi: 10.1111/1348-0421.12565.
PMID:29266585

総説

Translocation and dissemination of botulinum neurotoxin from the intestinal tract.
Fujinaga Y, Popoff MR.
Toxicon. 2018 Jun 1;147:13-18. doi: 10.1016/j.toxicon.2017.10.020.
PMID:29074396

2017年

論文業績

原著

Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies.
Kim MH, Sugawara Y, Fujinaga Y, Kino-Oka M.
Sci Rep. 2017 Mar 7;7(1):93. doi: 10.1038/s41598-017-00083-1.
PMID:28273902

2015年

論文業績

原著

Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3.
Sugawara Y, Iwamori M, Matsumura T, Yutani M, Amatsu S, Fujinaga Y.
FEBS J. 2015 Sep;282(17):3334-47. doi: 10.1111/febs.13346.
PMID:26077172

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity.
Matsumura T, Sugawara Y, Yutani M, Amatsu S, Yagita H, Kohda T, Fukuoka S, Nakamura Y, Fukuda S, Hase K, Ohno H, Fujinaga Y.
Nat Commun. 2015 Feb 17;6:6255. doi: 10.1038/ncomms7255.
PMID:25687350

総説

[Molecular targets of bacterial effectors and toxins that underlie vulnerability to diseases].
Shimizu T, Fujinaga Y, Takaya A, Ashida H, Kodama T, Hatakeyama M.
Nihon Saikingaku Zasshi. 2015;70(2):319-28. doi: 10.3412/jsb.70.319.
PMID:26028212

松村拓大、藤永由佳子

ボツリヌス神経毒素複合体の体内侵入機構

臨床免疫・アレルギー科　64巻1号、(65-69) 2015年7月　

藤永由佳子、松村拓大
腸管 M 細胞を介したボツリヌス毒素の侵入機構
感染 炎症 免疫　45巻、(175-184)2015年

2014年

論文業績

原著

Functional dissection of the Clostridium botulinum type B hemagglutinin complex: identification of the carbohydrate and E-cadherin binding sites.
Sugawara Y, Yutani M, Amatsu S, Matsumura T, Fujinaga Y.
PLoS One. 2014 Oct 23;9(10):e111170. doi: 10.1371/journal.pone.0111170. eCollection 2014.
PMID:25340348

2013年

論文業績

原著

Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections.
Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.
Microb Pathog. 2013 Dec;65:14-20. doi: 10.1016/j.micpath.2013.08.006.
PMID:24036179

Crystal structure of Clostridium botulinum whole hemagglutinin reveals a huge triskelion-shaped molecular complex.
Amatsu S, Sugawara Y, Matsumura T, Kitadokoro K, Fujinaga Y.
J Biol Chem. 2013 Dec 6;288(49):35617-25. doi: 10.1074/jbc.M113.521179.
PMID:24165130

総説

Uptake of botulinum neurotoxin in the intestine.
Fujinaga Y, Sugawara Y, Matsumura T.
Curr Top Microbiol Immunol. 2013;364:45-59. doi: 10.1007/978-3-642-33570-9_3.
PMID:23239348

藤永由佳子
重篤な食中毒を引き起こす細菌毒素の研究の最前線　志賀毒素（ベロ毒素）とボツリヌス毒素
ファルマシア　49巻、764-768 (2013)

​書籍

Fujinaga Y.*, Sugawara Y., Matsumura T. 
Uptake of botulinum neurotoxin in the intestine.In Rummel A. and Binz T. (eds.),
Botulinum Neurotoxins, Springer-Verlag, 45-59 (2013) [Curr. Top. Microbiol. Immunol. 364:45-59 (2013)] 

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